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Reducing onset time of cannabinoids
Reducing onset time of cannabinoids
An interesting finding from the PK Oral CBD study is that the emulsion delivery system achieved a higher plasma concentration of CBD (342 ng/ml) in 15 minutes compared to the maximum plasma concentrations achieved for CBD without a delivery system (26 ng/ml at 60 minutes) as well as CBD in a lipid delivery system (134 ng/ ml at 60 minutes). -
How do emulsions improve bioavailability?
How do emulsions improve bioavailability?
O/W emulsions are dispersions of oil droplets in an aqueous solution that are stabilized against separation by emulsifiers creating micelles or liposomes. Micelles are small particles that have a hydrophobic (water repelling) core surrounded by a hydrophilic (water compatible) shell. Liposomes are vesicles having an aqueous core surrounded by a lipid bi-layer with a hydrophobic interior and a hydrophilic exterior. -
How can cannabis oral bioavailability be increased?
How can cannabis oral bioavailability be increased?
It is possible to increase the oral bioavailability of cannabinoids by using drug delivery systems that promote solubilization. -
Infused products have low bioavailability
Infused products have low bioavailability
Cannabis edibles and oral dosage forms suffer from low bioavailability of cannabinoids. Cannabinoids are the active ingredients found in the plant and it's extracts. When taken orally only 4%-12% of the total cannabinoids consumed reach the bloodstream [1]. In comparison smoking cannabis can reach a bioavailability above 50% within minutes of inhalation [2-5]. Furthermore, the poor bioavailability of cannabinoids results in delayed onset; effects are typically felt between 60 to 120 minutes before [6]. -
Why is bioavailability important for cannabis infused products?
Why is bioavailability important for cannabis infused products?
Bioavailability directly influences the effects of cannabis infused products impacting their time of onset, intensity and duration. Designing products with bioavailability in mind aids in creating optimal dosages while minimizing any unwanted side effects. -
What is bioavailability?
Bioavailability is the proportion and rate a drug or active ingredient enters the bloodstream. Once in the bloodstream it can access the site of action and illicit a physiological response. -
If I use CBD will I fail a drug test?
I get this question quite frequently, here's a quick answer for you... First, it is important to understand your company policies. If you get drug...
