How can cannabis oral bioavailability be increased?

How can cannabis oral bioavailability be increased?

It is possible to increase the oral bioavailability of cannabinoids by using drug delivery systems that promote solubilization. Lipid delivery systems and oil-in-water (O/W) emulsion delivery systems are known to increase the bioavailability of lipophilic drugs through solubilization [10-12]. A pharmacokinetic study titled: Pharmacokinetics of CBD Taken Orally (PK Oral CBD) was conducted to evaluate the impact of these delivery systems on the bioavailability of a model cannabinoid: CBD. In the PK Oral CBD study, three formulas were compared: CBD with no delivery system, CBD in a lipid delivery system and CBD in Realize TM emulsion delivery system. The results of the PK Oral CBD study are presented in Figure 2.

 

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